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U.S. stocks were poised to open lower on Wednesday as investors took a breather from a rally that was sparked by the Federal Reserve's likely pivot to a dovish policy, while FedEx tumbled after issuing a grim outlook. .N

At 9:02 ET, Dow e-minis 1YMc1 were down 0.22% at 37,847. S&P 500 e-minis ESc1 were down 0.22% at 4,809.75, while Nasdaq 100 e-minis NQc1 were down 0.26% at 16,978.25.

The top three NYSE percentage gainers premarket .PRPG.NQ:
** Hyliion Holdings Corp , up 14.1%
** Four Seasons Education (Cayman) Inc , up 12.8%
** Forge Global Holdings , up 12.4%

The top two NYSE percentage losers premarket .PRPL.NQ:
** Nexa Resourcs SA , down 15.2%
** Argan Inc , down 13.3%


The top two Nasdaq percentage losers premarket .PRPL.O:
** Bluebird Bio Inc , down 48.8%
** Jin Medical International Ltd , down 42.4%


** Bluebird bio Inc BLUE.O: down 48.8% premarket
BUZZ - Falls after announcing pricing of common stock

** Cinemark Holdings Inc CNK.N: down 2.5% premarket
BUZZ - Down after brokerage Wells Fargo downgrades to 'underweight'

** Steelcase Inc SCS.N: down 7.7% premarket
BUZZ - Falls as Q3 revenue declines

** Paramount Global PARA.O: up 1.5% premarket
BUZZ - Gains after Wells Fargo upgrades on M&A hopes

** Passage Bio Inc PASG.O: up 18.0% premarket
BUZZ - Rises on positive early-stage data for dementia treatment

** Discover Financial Services DFS.N: up 1.7% premarket
BUZZ - Rises after Citigroup upgrades to 'buy', lifts PT

** General Mills Inc GIS.N: down 3.7% premarket
BUZZ - Down after cutting FY sales forecast

** Longeveron Inc LGVN.O: up 2.6% premarket
BUZZ - Rises on positive results from Alzheimer's treatment trial

** Winnebago Industries Inc WGO.N: down 4.6% premarket
BUZZ - Falls on Q1 profit miss

** Aon PLC AON.N: down 7.4% premarket
BUZZ - Slides after $13.4 bln deal to buy insurance broker NFP

** Immunovant Inc IMVT.O: down 10.8% premarket
BUZZ - Drops after failure of rival's autoimmune therapy

** Lowe's Companies Inc LOW.N: down 1.3% premarket
BUZZ - Falls after Stifel downgrades to 'hold'

** Alphabet Inc GOOGL.O: up 1.6% premarket
BUZZ - Rises after report says Google to restructure ad sales unit

(Compiled by Rajarshi Roy and Sneha S K)

((Sneha.sk@thomsonreuters.com))