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Wall Street's main indexes fell on Wednesday as growing tensions in the Middle East dented risk sentiment, with investors also focused on earnings to gauge the impact of inflation and high interest rates on businesses. .N

At 11:45 ET, the Dow Jones Industrial Average .DJI was down 0.50% at 33,827.35. The S&P 500 .SPX was down 0.76% at 4,340.13 and the Nasdaq Composite .IXIC was down 0.90% at 13,411.998.

The top three S&P 500 .PG.INX percentage gainers:
** Nasdaq Inc NDAQ.O, up 5.6%
** Dexcom DXCM.O, up 3.9%
** Valero Energy VLO.N, up 3.2%

The top three S&P 500 .PL.INX percentage losers:
** Albemarle ALB.N, down 9.9%
** United Airlines UAL.O, down 8.4%
** Bio-Rad Labs BIO.N, down 8.1%

The top three NYSE .PG.N percentage gainers:
** Spirit AeroSystems Holdings SPR.N, up 23.6%
** Houston American Energy HUSA.N, up 11.8%
** Indonesia Energy INDO.N, up 11.1%

The top two NYSE .PL.N percentage losers:
** Enviva Inc EVA.N, down 13.3%
** Li-Cycle Holdings LICY.N, down 11.9%

The top two Nasdaq .PG.O percentage gainers:
** Falcon's Beyond Global FBYDP.O, up 154.4%
** Sigma Additive Solutions SASI.O, up 65.3%

The top two Nasdaq .PL.O percentage losers:
** Nuzee Inc Ord NUZE.O, down 42.3%
** Bridger Aerospace Group BAER.O, down 26.6%

** Morgan Stanley MS.N: down 7.9%
BUZZ-Falls after Q3 profit drops on slow M&A activity

** Goldman Sachs GS.N: down 2.0%
BUZZ-Street View: Return on equity, writedowns in focus

** Ultragenyx Pharma RARE.O: down 10.9%
BUZZ-Slides after stock offering launch

** SolarEdge SEDG.O: down 5.2%
BUZZ-Falls after PT cuts on weak solar demand

** Procter & Gamble PG.N: up 1.9%
BUZZ-Rises after Q1 beat

** Winnebago Industries WGO.N down 2.7%
BUZZ-Falls on Q4 revenue miss

** Bridger Aerospace BAER.O down 26.6%
BUZZ-Dives after launching $70 mln stock offering

** Nikola NKLA.O down 7.1%
BUZZ-Down as brokerage expects deliveries in Q3

** SeaStar Medical ICU.O up 44.9%
BUZZ-Jumps on FDA's 'breakthrough' tag for liver disease treatment device

** Lululemon LULU.O down 1.1%
BUZZ-Dips in first day of trading in S&P 500

** Nvidia NVDA.O: down 3.6%

BUZZ-Extends losses on lingering concerns about US curbs

** United Airlines Holdings UAL.O: down 8.4%

BUZZ-Drops on downbeat profit forecast

** Chevron CVX.N: up 1.1%

** Exxon Mobil XOM.N: up 1.2%

** Occidental Petroleum OXY.N: up 1.8%

** Devon Energy DVN.N: up 0.9%

BUZZ-U.S. energy firms edge higher as oil spikes on escalation in Middle East strife

** Interactive Brokers Group IBKR.O: down 4.7%

BUZZ-Falls on tempered account growth forecast

** Freeline Therapeutics Holdings FRLN.O: up 11.6%

BUZZ-Rises on proposal for acquisition of all outstanding shares

** Ardelyx ARDX.O: up 15.2%
BUZZ-Gains as US FDA greenlights kidney disease-related drug

** Johnson & Johnson JNJ.N: down 1.9%
BUZZ-Street View: 2024 outlook looks hazy

** Southwestern Energy SWN.N: up 1.9%
BUZZ-Rises on potential acquisition by Chesapeake

** Abbott Laboratories ABT.N: up 2.9%
BUZZ-Rises as Q3 profit beats estimates on sales of devices, diagnostics

** Enphase ENPH.O: down 4.3%
BUZZ-Street View: Enphase to face tough 2023 with high inventory, Tesla competition

** Spirit AeroSystems SPR.N: up 23.6%
BUZZ-Announces agreement with Boeing; shares rise

** Visa V.N: down 1.1%

** Mastercard MA.N: down 1.3%
BUZZ-Slip on report Fed to lower debit-card swipe fees

** Roku ROKU.O: down 6.4%
BUZZ-Slips as Wells Fargo cuts PT on soft advertising trends

** SQM SQM.N: down 6.6%
BUZZ-Drops after BofA cuts to 'underperform'

The 11 major S&P 500 sectors:

(Compiled by Christy Santhosh in Bengaluru)

((christy.santhosh@thomsonreuters.com))