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U.S. stock index futures were subdued on Wednesday as skittish investors waited for the Federal Reserve to cut interest rates for the first time in more than four years, with most traders betting on a half-percentage-point reduction. .N

At 7:32 ET, Dow e-minis 1YMc1 were up 0.14% at 41,698. S&P 500 e-minis ESc1 were up 0.15% at 5,647.25, while Nasdaq 100 e-minis NQc1 were up 0.22% at 19,482.25.

The top three NYSE percentage gainers premarket .PRPG.NQ:
** Bausch Health , up 4.6%
** Sos , up 4.3%
** Permianville Royalty Trust , up 4.2%

The top three NYSE percentage losers premarket .PRPL.NQ:
** Kuke Music Holding , down 5.9%
** Knowles , down 5%
** Genius Sports , down 3.8%

The top two Nasdaq percentage gainers premarket .PRPG.O:
** Portage Biotech , up 125.8%
** Odyssey Marine Exploration , up 83.4%

The top Nasdaq percentage loser premarket .PRPL.O:
** Galmed Pharmaceuticals , down 24.2%

** 23andMe Holding ME.O: down 9.6% premarket
BUZZ - Down after independent directors quit board

** Intuitive Machine LUNR.O: up 53.1% premarket
BUZZ - Jumps on $4.8 bln contract from NASA

** GE Healthcare Technologies GEHC.O: up 1.1% premarket
BUZZ - BTIG upgrades GE Healthcare to 'buy'

** VF VFC.N: up 3.0% premarket
BUZZ - Up after Barclays raises to 'overweight', hikes PT

** i-80 Gold IAUX.N: up 9.3% premarket
BUZZ - Names new CEO; shares rise

** Cibus CBUS.O: down 18.0% premarket
BUZZ - Slides on stock offering plans

(Compiled by Rajarshi Roy and Neil J Kanatt)

((Neil.JKanatt@thomsonreuters.com))