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Wall Street's main indexes fell on Wednesday after latest inflation hit expectations of a bigger interest rate cut by the Federal Reserve, while odds of Democrat Kamala Harris winning the U.S. presidency rose following a televised debate. .N

At 11:36 ET, the Dow Jones Industrial Average .DJI was down 1.2% to 40,235.01. The S&P 500 .SPX was down 1.10% at 5,435.29 and the Nasdaq Composite .IXIC was down 0.78% at 16,892.726.

The top three S&P 500 .PG.INX percentage gainers:
** First Solar , up 11.3%
** Albemarle , up 10.6%
** AES Corp , up 6.6%

The top three S&P 500 .PL.INX percentage losers:
** Humana Inc , down 5.1%
** Carmax Inc , down 4.7%
** Rollins Inc , down 4.7%

The top two NYSE .PG.N percentage gainers:
** Mesabi Trust , up 28.6%
** Evolution Petroleum Corp , up 17.1%

The top two NYSE .PL.N percentage losers:
** Torrid Holdings , down 24.7%
** Rentokil Initial , down 20.3%

The top three Nasdaq .PG.O percentage gainers:
** Children's Place , up 65.6%
** Purecycle Technologies , up 33%
** Petco Health and Wellness , up 31.9%

The top three Nasdaq .PL.O percentage losers:
** Laser Photonics , down 41.3%
** Trident Digital , down 25.6%
** Allarity Therapeutics , down 20.4%

** Coinbase Global Inc COIN.O: down 2.9%

** Bitfarms Ltd BITF.O: down 3.5%

** Riot Platforms Inc RIOT.O: down 3.7%

** Marathon Digital Holdings Inc MARA.O: down 1.7%
BUZZ - Crypto stocks track bitcoin lower after Trump-Harris presidential debate

** GameStop Corp GME.N: down 14.5%
BUZZ - Slips on Q2 rev decline, files 20 mln stock offering

** Trump Media & Technology Group Corp DJT.O: down 12.9%
BUZZ - Slides as odds of Trump win dip following debate

** Bank of America Corp BAC.N: down 2.7%
BUZZ - Dips as Buffett's Berkshire extends selling spree

** Albemarle Corp ALB.N: up 10.6%

** Arcadium Lithium PLC ALTM.N: up 12.6%

** Piedmont Lithium Inc PLL.O: up 6.1%

** Lithium Americas Corp LAC.N: up 6.3%
BUZZ - Lithium miners gain after China's CATL says it will adjust production

** Relay Therapeutics Inc RLAY.O: down 17.4%
BUZZ - Drops on deep-discounted $200 mln equity offering

** Cantaloupe Inc CTLP.O: down 5.5%
BUZZ - Slips on lackluster Q4 results

** Maxeon Solar Technologies Ltd MAXN.O: up 4.0%

** Jinkosolar Holding Co Ltd JKS.N: up 3.4%

** Enphase Energy Inc ENPH.O: up 5.3%

** Canadian Solar Inc CSIQ.O: up 9.9%
BUZZ - Solar stocks gain as odds of Harris win rise after presidential debate

** Designer Brands Inc DBI.N: down 15.1%
BUZZ - Tumbles on cutting annual profit forecast

** Orion Group Holdings Inc ORN.N: down 10.6%
BUZZ - Tumbles on pricing stock offering

** GEO Group Inc GEO.N: down 7.5%

** CoreCivic Inc CXW.N: down 5.9%
BUZZ - Falls after Harris-Trump debate

** Manchester United PLC MANU.N: down 5.1%
BUZZ - Falls on posting bigger annual loss

** Canadian National Railway Co CNI.N: down 1.6%

** Raymond James Financial Inc RJF.N: down 1.6%
BUZZ - Brokerages lower Canadian National Railway PT after profit forecast cut; shares down

** BridgeBio Pharma Inc BBIO.O: down 3.3%
BUZZ - To stop development of genetic disorder therapy, shares fall

** Children's Place Inc PLCE.O: up 65.6%
BUZZ - Soars as lower expenses boost Q2 profit

** Centrus Energy Corp LEU.N: up 5.4%
BUZZ - Up on signing supply commitment with Korean firm

** Viking Therapeutics Inc VKTX.O: up 9.2%
BUZZ - Surges after JPM's 'overweight' rating

** Petco Health and Wellness Company Inc WOOF.O: up 31.9%
BUZZ - Reverses course after brokerages lift PT

** Vera Bradley Inc VRA.O: down 8.3%
BUZZ - Falls on lowered annual forecasts, Q2 sales miss

** Williams-Sonoma Inc WSM.N: up 1.1%
BUZZ - Rises after Jefferies upgrades to "buy"

** Applied DNA Sciences Inc APDN.O: up 21.9%
BUZZ - Rises after expanding mpox testing service

** SentinelOne Inc S.N: down 1.0%
BUZZ - Falls after hiring CFO

** Newmont Corp NEM.N: down 1.7%

** Barrick Gold Corp GOLD.N: down 0.3%

** Gold Fields Ltd GFI.N: down 1.6%

** AngloGold Ashanti Ltd AU.N: down 2.1%
BUZZ - Gold miners fall after US data dims hopes of over-sized rate cut

** Uranium Energy Corp UEC.N: up 7.1%

** Energy Fuels Inc UUUU.N: up 6.7%

** Ur-Energy Inc URG.N: up 5.0%

** NexGen Energy Ltd NXE.N: up 5.8%
BUZZ - Uranium miners rise after Putin says Russia should limit exports

** UnitedHealth Group Inc UNH.N: down 2.5%

** CVS Health Corp CVS.N: down 3.3%

** Humana Inc HUM.N: down 5.1%
BUZZ - Health insurers fall after bets on Harris win rise after debate

** Torrid Holdings Inc CURV.N: down 24.7%
BUZZ - Shares frigid as PE sponsor, CEO to cut stakes

The 11 major S&P 500 sectors:

(Rajarshi Roy and Sneha S K)

((Rajarshi.Roy@thomsonreuters.com))