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Updated at 9:49 a.m. ET
By Shashwat Chauhan and Lisa Pauline Mattackal
Sept 11 (Reuters) - Wall Street's main indexes fell on Wednesday after latest inflation hit expectations of a bigger interest rate cut by the Federal Reserve, while odds of Democrat Kamala Harris winning the U.S. presidency rose following a televised debate.
Consumer prices in the United States increased marginally in August, but underlying inflation showed some stickiness, which could discourage the Fed from delivering a half-point rate cut week.
"The Fed would have liked to have seen softer in order to justify a potential 50-basis point cut at the upcoming meeting ... but this (data) probably makes it more likely that they proceed with a 25-bps cut," Jason Pride, chief of investment strategy and research at Glenmede, said.
The consumer price index (CPI) increased 0.2% last month after climbing 0.2% in July, the Labor Department's Bureau of Labor Statistics said.
The core figure, excluding volatile food and energy components, rose 0.3% on a monthly basis against forecasts of a 0.2% rise.
Traders see an 85% chance of the Fed cutting interest rates by 25 basis points, according to CME's FedWatch.
Market sentiment was also driven by political developments after Harris put her Republican rival Donald Trump on the defensive in a combative presidential debate on Tuesday.
After the debate, pricing for a Trump victory slipped by 6 cents to 47 cents on online betting site PredictIt, while climbing to 57 cents from 53 cents for a Harris win.
Stocks expected to perform well under a Trump presidency fell, with cryptocurrency and blockchain-related shares and prison operators lower. Trump Media & Technology Group DJT.O slumped 17%.
Meanwhile, solar stocks Sunrun RUN.O and SolarEdge Technologies SEDG.O, seen as benefiting from a Harris administration, rose more than 7% each.
While the debate offered Wall Street little clarity on key policy issues, some market watchers see Harris' proposals to raise the corporate tax rate as likely to hit company profits, while Trump's tougher stance on tariffs could stoke inflation.
Chip stocks kept Nasdaq's losses in check. The Philadelphia SE Semiconductor index .SOX rose 1.2%, led by a 3.5% jump in the shares of industry heavyweight Nvidia NVDA.O.
At 09:49 a.m. ET, the Dow Jones Industrial Average .DJI fell 448.74 points, or 1.15%, to 40,281.08, the S&P 500 .SPX lost 32.33 points, or 0.63%, to 5,463.19, and the Nasdaq Composite .IXIC lost 1.73 points, or 0.02%, to 17,023.12.
Among other stocks, GameStop GME.N dropped 12.3% after the videogame retailer said it had filed for an offering of up to 20 million shares and reported lower second-quarter revenue.
Shares of lithium miners jumped after Chinese battery giant CATL 300750.SZ said it plans to make adjustments to lithium carbonate production in Yichun based on recent market conditions. Albemarle ALB.N, one of the largest lithium miners in the world, jumped 13.5%.
Declining issues outnumbered advancers for a 2.43-to-1 ratio on the NYSE and a 1.76-to-1 ratio on the Nasdaq.
The S&P 500 posted five 52-week highs and five lows, while the Nasdaq Composite recorded 55 lows.
(Reporting by Shashwat Chauhan and Lisa Mattackal in Bengaluru; Editing by Shounak Dasgupta)