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Wall Street's main indexes were set to open lower on Wednesday as fresh worries over the health of the U.S. economy kept investors on the sidelines in the run-up to labor data. .N

At 9:06 ET, Dow e-minis 1YMc1 were down 0.12% at 40,967. S&P 500 e-minis ESc1 were down 0.30% at 5,525.25, while Nasdaq 100 e-minis NQc1 were down 0.57% at 18,899.

The top three NYSE percentage gainers premarket .PRPG.NQ:
** Brookfield Business Partners , up 18.1%
** Markforged , up 12.8%
** Cion Investment , up 8.0%

The top two NYSE percentage losers premarket .PRPL.NQ:
** Core & Main , down 14.6%
** Asana , down 14.2%

The top Nasdaq percentage gainer premarket .PRPG.O:
** WiSA Technologies , up 67.6%

The top two Nasdaq percentage losers premarket .PRPL.O:
** Athira Pharma , down 75.3%
** Shuttle Pharmaceuticals , down 26.9%


** Nvidia Corp NVDA.O: down 1.4% premarket
BUZZ - Set to extend rout after report of subpoena from US DoJ

** Zscaler Inc ZS.O: down 16.9% premarket
BUZZ - Falls on downbeat FY25 forecast as clients spend less on cybersecurity

** Athira Pharma Inc ATHA.O: down 75.3% premarket
BUZZ - Tumbles after Alzheimer's drug fails trial

** Starwood Property Trust Inc STWD.N: down 4.1% premarket
BUZZ - Falls on pricing $345 mln stock offering

** Dollar Tree Inc DLTR.O: down 12.5% premarket
BUZZ - Slides after trimming annual profit, sales forecasts

** Hormel Foods Corp HRL.N: down 8.0% premarket
BUZZ - Falls after annual sales forecast cut

** Shift4 Payments Inc FOUR.N: up 0.5% premarket
BUZZ - Gets 'outperform' rating as William Blair starts coverage

** RingCentral Inc RNG.N: down 2.6% premarket
BUZZ - Falls after CFO resigns

** PagerDuty Inc PD.N: down 10.6% premarket
BUZZ - Falls as brokerages cut PT after it trims annual revenue outlook

** Sweetgreen Inc SG.N: up 2.6% premarket
BUZZ - Rises after TD Cowen upgrades to 'buy'

** Independence Realty Trust Inc IRT.N: down 3.4% premarket
BUZZ - Drops on pricing 10 mln share offering

** GitLab Inc GTLB.O: up 12.2% premarket
BUZZ - Rises on annual forecast raise

** TPI Composites Inc TPIC.O: up 0.2% premarket

** GE Vernova Inc GEV.N: up 0.4% premarket
BUZZ - Picks for exposure to US wind energy sector, says Evercore

** Advanced Micro Devices Inc AMD.O: up 2.6% premarket
BUZZ - Shares rise as co hires former Nvidia executive Keith Strier

(Reporting by Rajarshi Roy and Juveria Tabassum)

((Juveria.Tabassum@thomsonreuters.com;))