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Wall Street's main indexes were lower on Tuesday, weighed down by tech-related stocks, as caution prevailed ahead of a highly anticipated earnings report from Nvidia and crucial economic data expected later in the week. .N

At 11:41 ET, the Dow Jones Industrial Average .DJI was down 0.25% at 41,137.9. The S&P 500 .SPX was down 0.07% at 5,612.98 and the Nasdaq Composite .IXIC was down 0.11% at 17,706.13.

The top three S&P 500 .PG.INX percentage gainers:
** Insulet Corp PODD.O, up 7.3%
** Resmed Inc RMD.N, up 5.9%
** Align Technology Inc ALGN.O, up 2.5%

The top three S&P 500 .PL.INX percentage losers:
** Paramount Global PARA.O, down 5.3%
** Walgreen Boots Alliance Inc WBA.O, down 4.8%
** Martin Marietta Materials Inc MLM.N, down 4.6%

The top three NYSE .PG.N percentage gainers:
** ProShares UltraShort Ether ETF ETHD.N, up 12%
** North European Oil Royalty Trust NRT.N, up 7%
** Energizer Holdings Inc ENR.N, up 6.5%

The top three NYSE .PL.N percentage losers:
** Gaotu Techedu Inc GOTU.N, down 14.7%
** AdvisorShares Pure US Cannabis ETF MSOS.N, down 12%
** Lumen Technologies Inc LUMN.N, down 10.5%

The top three Nasdaq .PG.O percentage gainers:
** VOXX International Corp VOXX.O, up 60.2%
** Trinity Biotech PLC TRIB.O, up 45.8%
** Addex Therapeutics Ltd ADXN.O, up 43.6%

The top three Nasdaq .PL.O percentage losers:
** Cosciens Biopharma Inc CSCI.O, down 33.8%
** Lifecore Biomedical Inc LFCR.O, down 21.4%
** Bolt Projects Holdings Inc BSLK.O, down 17.8%

** Paramount Global PARA.O: down 5.2%
BUZZ - Slides as Edgar Bronfman abandons bid

** Gaotu Techedu Inc GOTU.N: down 14.7%
BUZZ - Falls after posting Q2 loss

** Trip.com Group Ltd TCOM.O: up 9.7% premarket
BUZZ - Rises after Q2 results

** Hershey Co HSY.N: down 1.8%
BUZZ - Falls as Citi downgrades to 'sell' on cocoa inflation, weak demand

** Trinity Biotech PLC TRIB.O: up 45.8%
BUZZ - Rises after raising sales forecast for HIV test

** Cava Group Inc CAVA.N: down 5.8%
BUZZ - To ease from post-IPO record high as execs, top holder sell shares

** Insulet Corp PODD.O: up 7.4%
BUZZ - Jumps after FDA clears expanded use of insulin delivery system

** Coinbase Global Inc COIN.O: down 4.3%

** Bitfarms Ltd BITF.O: down 5.9%

** Riot Platforms Inc RIOT.O: down 6.3%
** Hut 8 Mining Corp HUT.O: down 8.1%
BUZZ - Crypto shares down on bitcoin weakness

** Cosciens Biopharma Inc CSCI.O: down 33.8%
BUZZ - Slides on trial failure of growth hormone deficiency diagnostic drug

** Ensysce Bioscience Inc ENSC.O: up 38.8%
BUZZ - Rises on US government grant for its pain relief drug

** PDD Holdings Inc PDD.O: down 3.9%
BUZZ - ADRs ease as Citi downgrades to '' following record slump

** SNDL Inc SNDL.O: down 4.3%

** Organigram Holdings Inc OGI.O: down 7.0%
** Tilray Brands Inc TLRY.O: down 5.4%
** Cronos Group Inc CRON.O: down 4.1%
BUZZ - Pot stocks fall as US drug agency to hold reclassification hearing after elections

** Leslie's Inc LESL.O: down 9.9%
BUZZ - Slides after announcing CEO transition

** JD.com Inc JD.O: up 2.8%
BUZZ - Jumps on buyback plan

** First Busey Corp BUSE.O: down 2.1%
BUZZ - Dips after CrossFirst deal

** Hims & Hers Health Inc HIMS.N: down 7.4%

** LifeMD Inc LFMD.O: down 7.9%

** Teladoc Health Inc TDOC.N: down 2.4%
BUZZ - Telehealth firms fall after Lilly launches single-dose vials of weight-loss drug

** Eli Lilly and Co LLY.N: up 0.8%
BUZZ - Rises after launching single-dose vials of weight-loss drug for $399

** Super Micro Computer Inc SMCI.O: down 3.2%
BUZZ - Drops after Hindenburg discloses short position

** Lumen Technologies Inc LUMN.N: down 10.5%
BUZZ - Slides after Kerrisdale discloses short position

** Cleveland-Cliffs Inc CLF.N: up 0.7%
BUZZ - Edges higher after Seaport Research upgrades to "buy"

** Soleno Therapeutics Inc SLNO.O: up 4.1%
BUZZ - Rises as FDA grants priority review for genetic disorder treatment

** BILL Holdings Inc BILL.N: up 6.2%
BUZZ - Jumps after top executives buy stake

The 11 major S&P 500 sectors:

(Compiled by Rajarshi Roy and Pooja Menon in Bengaluru)

((Rajarshi.Roy@thomsonreuters.com))