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It’s time to dive into the biggest pre-market stock movers for Wednesday morning as we check out all of the hottest news to start the day with!

Moving stocks this morning a partnerships, a public offering, clinical trial news and more.

Let’s get into that news below!

Biggest Pre-Market Stock Movers: 10 Top Gainers

1. Dermata Therapeutics (NASDAQ:DRMA) stock is rocketing more than 123% alongside heavy pre-market trading.
2. Nuzee (NASDAQ:NUZE) shares are soaring over 75% with strong early morning trading.
3. Hoth Therapeutics (NASDAQ:HOTH) stock is surging more than 45% on a new partnership to develop its Alzheimer’s treatment.
4. Allarity Therapeutics (NASDAQ:ALLR) shares are increasing over 44% after encouraging investors to vote for a reverse stock split.
5. Regencell Bioscience (NASDAQ:RGC) stock is heading more than 33% higher alongside strong pre-market trading.
6. Pieris Pharmaceuticals (NASDAQ:PIRS) shares are rising over 28% after announcing a merger agreement.
7. Bone Biologics (NASDAQ:BBLG) stock is jumping more than 23% with heavy early morning trading today.
8. NewGenIvf (NASDAQ:NIVF) shares are climbing over 22% after providing a reverse merger update.
9. Perfect Moment (NYSEMKT:PMNT) stock is getting a close to 19% boost after announcing a distribution center agreement.
10. Catheter Precision (NYSEMKT:VTAK) shares are up more than 16% without any clear news this morning.

10 Top Losers

1. Azitra (NYSEMKT:AZTR) stock is crashing over 73% but only after a massive rally yesterday.
2. Conn’s (NASDAQ:CONN) shares are plummeting 28% on reports of impending store closures.
3. ATI Physical Therapy (NYSE:ATIP) stock is diving more than 25% without any obvious news this morning.
4. Verastem (NASDAQ:VSTM) shares are tumbling over 25% on a proposed public offering.
5. Agape ATP (NASDAQ:ATPC) stock is taking an almost 24% beating after a rally yesterday.
6. AtlasClear (NYSEMKT:ATCH) shares are sliding more than 22% despite a lack of news on Wednesday.
7. Sage Therapeutics (NASDAQ:SAGE) stock is dropping over 22% after reporting Phase 2 topline results.
8. Volato (NYSEMKT:SOAR) shares are decreasing more than 21% after a recent rally.
9. Chijet Motor (NASDAQ:CJET) stock is slipping over 19% following yesterday’s rally.
10. Salarius Pharmaceuticals (NASDAQ:SLRX) shares close out our pre-market stock movers down more than 19% after a rally yesterday.

On the date of publication, William White did not have (either directly or indirectly) any positions in the securities mentioned in this article. The opinions expressed in this article are those of the writer, subject to the InvestorPlace.com Publishing Guidelines.

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