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Wall Street's main stock indexes ticked higher on Wednesday, with the blue-chip Dow leading gains in thin trading ahead of crucial economic data, commentary from the Federal Reserve's policymakers and a long holiday weekend. .N

At 11:32 ET, the Dow Jones Industrial Average .DJI was up 0.55% at 39,499.23. The S&P 500 .SPX was up 0.21% at 5,214.56 and the Nasdaq Composite .IXIC was down 0.17% at 16,287.454.

The top three S&P 500 .PG.INX percentage gainers:
** Cintas , up 9.6%
** Enphase Enrgy , up 8.5%
** First Solar , up 6.7%

The top three S&P 500 .PL.INX percentage losers:
** Arista Networks , down 4.4%
** Global Payments , down 3.6%
** NVIDIA Corp , down 3.5%

The top three NYSE .PG.N percentage gainers:
** GCT Semicodutor , up 169.5%
** iBio , up 144.1%
** Ouster , up 42%

The top two NYSE .PL.N percentage losers:
** Chromocell Therapeutics , down 25.1%
** GameStop , down 15.1%

The top three Nasdaq .PG.O percentage gainers:
** Stoke Therapeutics , up 43.7%
** Lixte Biotechnology , up 39.2%
** ONE Group Hospitality , up 24.9%

The top three Nasdaq .PL.O percentage losers:
** Wetouch Technology , down 38.6%
** RYVYL , down 38.1%
** Direct Digital Holdings , down 37.4%

** Merck & Co Inc MRK.N: up 3.9%
BUZZ - Hits record high as FDA approves therapy for rare lung condition

** Paysign Inc PAYS.O: up 21.3%
BUZZ - Surges on strong revenue forecast

** GameStop Corp GME.N: down 15.1%
BUZZ - Drops as competition, slow consumer spending weigh on Q4 revenue

** Forge Global Holdings Inc FRGE.N: down 25.7%
BUZZ - Dips after bigger-than-expected Q4 loss

** Moderna Inc MRNA.O: up 1.5%
BUZZ - Rises on $750 mln funding agreement with Blackstone Life Sciences

** Direct Digital Holdings Inc DRCT.O: down 37.4%
BUZZ - Falls after results, outlook miss

** Kimberly-Clark Corp KMB.N: up 0.7%
BUZZ - Gains on business reorganization

** General Electric Co GE.N: up 3.0%
BUZZ - Wells Fargo upgrades PT on General Electric over cost cutting potential

** Novocure Ltd NVCR.O: up 15.8%
BUZZ - Surges as cancer therapy succeeds in late-stage trial

** Altimmune Inc ALT.O: down 4.7%
BUZZ - Falls on failure of hepatitis B treatment trial

** Bowman Consulting Group Ltd BWMN.O: down 11.6%
BUZZ - Slides on pricing $50 mln stock offering

** Cintas Corp CTAS.O: up 9.5%
BUZZ - Hits record high after uniform rental firm raises annual forecasts

** Newmont Corp NEM.N: up 2.8%

** Barrick Gold Corp GOLD.N: up 2.2%

** Harmony Gold Mining Co Ltd HMY.N: up 3.0%

** Kinross Gold Corp KGC.N: up 2.1%
BUZZ - Gold miners rise on stronger bullion ahead of US inflation data

** Roivant Sciences Ltd ROIV.O: up 8.9%
BUZZ - Rallies as co poised to join S&P MidCap index

** Liquidia Corp LQDA.O: down 4.5%
BUZZ - Falls as rival Merck's therapy for lung condition gets FDA approval

** Spirit Airlines Inc SAVE.N: down 2.2%
BUZZ - Falls after Barclays reinstates with "underweight" rating

** Reddit Inc RDDT.N: down 13.1%
BUZZ - Shares down 14% in fifth day of trading

** Stoke Therapeutics Inc STOK.O: up 43.7%
BUZZ - Surges again after stock offering launch

The 11 major S&P 500 sectors:

(Compiled by Rajarshi Roy and Vallari Srivastava)

((Srivastava.Vallari@thomsonreuters.com;))