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The benchmark S&P 500 and the tech-laden Nasdaq touched two-week highs on Wednesday, as lower Treasury yields boosted megacaps, while investors keenly awaited inflation reports and earnings from major lenders later in the week. .N

At 10:44 ET, the Dow Jones Industrial Average .DJI was up 0.20% at 37,598.54. The S&P 500 .SPX was up 0.25% at 4,768.52 and the Nasdaq Composite .IXIC was up 0.39% at 14,916.197.

The top three S&P 500 .PG.INX percentage gainers:
** Intuitive Surgical ISRG.O, up 5.5%
** Lennar Corporation LEN.N, up 3.5%
** Howmet Aerospace HWM.N, up 3.4%

The top three S&P 500 .PL.INX percentage losers:
** Charles River Laboratories International CRL.N, down 4.3%
** Quest Diagnostics Incorporated DGX.N, down 3.8%
** IQVIA Holdings IQV.N, down 3.3%

The top three NYSE .PG.N percentage gainers:
** Ampio Pharmaceuticals AMPE.N, up 26.6%
** Stereotaxis STXS.N, up 19.7%
** E2open Parent Holdings ETWO.N, up 8.6%

The top two NYSE .PL.N percentage losers:
** China Green Agriculture CGA.N, down 11.4%
** Pinstripes Holdings PNST.N, down 9.9%

The top three Nasdaq .PG.O percentage gainers:
** Sana Biotechnology SANA.O, up 44.9%
** Clearmind Medicine CMND.O, up 44.4%
** Ucommune International UK.O, up 34.6%

The top three Nasdaq .PL.O percentage losers:
** DocGo DCGO.O, down 35.3%
** HWH International HWH.O, down 29.1%
** Pono Capital Three PTHR.O, down 24.4%

** General Dynamics GD.N: up 0.5%

** Lockheed Martin LMT.N: up 0.4%

** Northrop Grumman NOC.N: up 0.8%

** RTX RTX.N: up 0.4%
BUZZ - Bernstein raises PTs for defense firms on heightened global geopolitical tensions

** Aehr Test Systems AEHR.O: down 14.3%
BUZZ - Slides after cutting FY24 revenue forecast

** Intuitive Surgical ISRG.O: up 5.5%
BUZZ - Rises after prelim Q4 revenue beats estimates

** Home Depot HD.N: up 1.8%
BUZZ - Rises as Wedbush upgrades on expectations of strong demand in 2024

** Energy Fuels UUUU.N: up 1.3%

** Uranium Energy UEC.N: up 3.0%

** Global X Uranium ETF URA.N: up 2.5%
BUZZ - Uranium miners rise as US DOE pushes for enrichment contracts for HALEU

** Aclaris Therapeutics ACRS.O: down 19.8%
BUZZ - Falls after mid-stage trial setback for dermatitis drug

** Amarin Corporation PLC AMRN.O: up 23.6%
BUZZ - Rises as prelim Q4 revenue beats estimates

** SMART Global Holdings SGH.O: up 14.0%
BUZZ - Rises on upbeat forecast, Q1 profit beat

** Chewy CHWY.N: down 4.1%
BUZZ - Drops as Morgan Stanley shops big block

** Xeris Biopharma Holdings XERS.O: up 12.4%
BUZZ - Climbs on Amgen collaboration to develop eye disease treatment

** Taseko Mines TGB.N: up 9.1%
BUZZ - Rises on higher quarterly copper production

** DocGo DCGO.O: down 35.3%
BUZZ - Slumps after Fuzzy Panda Research discloses short position

** Charles Schwab SCHW.N: down 1.0%
BUZZ - Slips as Citi downgrades to ''

** Lennar LEN.N: up 3.5%

** D R Horton DHI.N: up 1.9%

** Pultegroup PHM.N: up 1.7%
BUZZ - Climbs after raising dividend, buyback

** Tigo Energy TYGO.O: up 7.3%
BUZZ - Gains on patent issuance

** Palo Alto Networks PANW.O: up 3.3%
BUZZ - Climbs as MS, Citigroup lift PTs

** Masimo MASI.O: up 2.3%
BUZZ - Rises on upbeat prelim Q4 revenue, forecast

** GoodRx Holdings GDRX.O: up 13.1%
BUZZ - Rises on upbeat prelim Q4 2023 revenue

** Arrowhead Pharmaceuticals ARWR.O: up 4.3%
BUZZ - Up after BofA raises stock PT

** AerCap Holdings NV AER.N: up 1.9%

** Air Lease AL.N: up 1.3%
BUZZ - Aircraft lessors rise as BMO starts coverage with 'outperform' rating

The 11 major S&P 500 sectors:

(Compiled by Anuja Bharat Mistry and Rajarshi Roy)

((AnujaBharat.Mistry@thomsonreuters.com))